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KMID : 0869619980150030379
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Journal of Korean Society of Hospital Pharmacists
1998 Volume.15 No. 3 p.379 ~ p.383
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Dissolution Rate and Content Uniformity of Enalapril Maleate Tablets
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Abstract
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Drug effect is depend on bioavailability of preparation and also bioavailability is largely depend on dissoution rate. This study was attempted to evaluate bioavailability of preparations for drug choice among many preparations by the dissolution test and content uniformity test of commercial enalapril maleate tablets. The dissolution test was conducted in artificial gastric juice and dissolution medium (USP) using Paddle method with five enalapril maleate preparations (A, B, C, D and E) which were pharmaceutically equivalent. The results were as follows : 1) The dissolution rate in artificial gastric juice was higher in order of five different brands B > D > E > A > C. 2) The dissolution rate in dissolution medium (USP) was higher in order of five different brands E > B > D > A > C. 3) Content uniformity of five different brands was better in such order as E > B > C > D > A.
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